Epithalon
A synthetic tetrapeptide derived from the pineal gland epithalamin, studied for its telomerase-activating and circadian-regulatory properties.
Epithalon (Epitalon, Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on the structure of epithalamin, a natural polypeptide extracted from the bovine pineal gland. It was first characterised by Russian gerontologists in the 1980s and has since accumulated a substantial preclinical research record focused on its relationship with telomere biology, with studies reporting stimulation of telomerase activity in somatic cell lines — a mechanism of considerable interest in longevity and cellular ageing research.
Beyond telomere biology, Epithalon research has explored its effects on melatonin synthesis via pinealocyte stimulation, suggesting a role in circadian rhythm regulation. Investigators have also reported effects on antioxidant enzyme activity (superoxide dismutase, catalase), tumour suppressor gene expression, and immune senescence markers in aged animal cohorts, positioning Epithalon as a multi-pathway probe for ageing biology.
The peptide's small size confers metabolic stability advantages relative to larger peptide analogues, and its low molecular weight facilitates tissue distribution in experimental models. It remains an important reference compound in the field of bioregulatory peptides and geropeptide research originating from the Russian academic tradition.
For research purposes only. Not for human consumption.