TB-500 (Thymosin Beta-4)
A synthetic analogue of the ubiquitous actin-sequestering protein Thymosin Beta-4, studied for its roles in cellular migration and repair.
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a 43-amino-acid protein expressed in nearly all mammalian cells and best characterised for its ability to sequester G-actin and regulate actin polymerisation dynamics. This cytoskeletal function places Tβ4 at the interface of cell motility, wound contraction, and inflammatory resolution — processes central to tissue repair research.
Studies in rodent and larger animal models have examined TB-500's influence on muscle satellite cell activation, endothelial sprouting, and keratinocyte migration, implicating the peptide in multiple phases of the repair cascade. Researchers have also documented its effects on anti-inflammatory cytokine profiles, cardioprotection after ischaemic injury, and neuronal recovery models, broadening its investigative utility beyond musculoskeletal applications.
As a water-soluble, systemically distributed peptide with low immunogenicity in preclinical assays, TB-500 provides a tractable tool for dissecting the biological roles of the thymosin family. Its straightforward reconstitution and dose-response relationships make it a staple in recovery and regenerative biology research programmes.
For research purposes only. Not for human consumption.